Research lines

• Myeloma and other monoclonal gammapathies

  Multiple myeloma and systemic AL amyloidosis. Minimal residual disease, extramedullary involvement in myeloma, cardiac involvement in amyloidosis, and multicentric clinical trials with novel drugs.

• Mechanisms of progression in monoclonal gammopathies

  Mechanisms of  progression and control in patients with multiple myeloma. Molecular and cellular features of  patients with long-lasting stable monoclonal gammopathy of undetermined significance and smoldering myeloma. Oligoclonal response and minimal residual disease in myeloma: impact of immune reconstitution and bone marrow microenvironment. Immunotherapy in monoclonal gammopathies. Clinical trials with novel molecules in myeloma and macroglobulinemia.

• Myeloid neoplasmas

  Natural history and prognosis of chronic myeloid leukemia, myeloproliferative neoplasms, acute myeloid leukemia and myelodysplastic syndromes; prognostic importance of newer molecular markers in these diseases; clinical trials with new drugs.

• Lymphoid neoplasms

  Lymphomas, chronic lymphocytic leukemia and the other lymphoproliferative disorders:

  Study of progression mechanisms of the disease, genome of CLL and lymphoma, minimum residual disease and biological prognostic models.