Thyroid eye disease progression

Generally, there is a chronological relationship between the onset of thyroid eye disease and hyperthyroidism, such that 60-85% of patients have both diseases, which manifest within a maximum of 18 months. However, there may also be spontaneous remission of the pathology within this period. 

In the early phases, thyroid eye disease tends towards progressive deterioration of vision, as inflammation increases. 

Later, a stabilisation phase is reached and, finally, a chronic phase, where the inflammatory process gives way to fibrous tissue (a type of dense connective tissue, composed of bundles of collagen fibres).