Líneas de investigación

• Dermoscopy, digital dermoscopy, confocal microscopy and new photonic and physic technologies

  Description of new algorithms, study of the evolution of lesions, new classifications and the use of telemedicine. Correlation of dermoscopy and molecular signatures. Implementation of fluorescent confocal microscopy in Mohs surgery and intraoperative diagnosis of several cancers. Development of OCT-HD, multispectral imaging & 3D imaging of the skin. Implementation of artificial technology for the classification of skin tumors.

• Genetic epidemiology in melanoma and non-melanoma skin cancer

  Study of melanoma susceptibility genes in familial and sporadic melanoma. Identification of new genes and mechanisms of melanoma susceptibility using genome wide analyses and next generation sequencing. Study of nevogenicity and pigmentation genes associated to risk in melanoma. Study of MC1R gene as medium penetrance gene and its implication in several types or subtypes of tumors and other pathologies. Study of genetic background of other cutaneous pathologies.

• Giant congenital nevi

  Global research approach including clinical, genetics and psychological aspects of giant congenital nevi.

• Identification of genetic prognostic profiles in melanoma

  Evaluation of germline genetic factors implicated in the modulation of melanoma outcome. Evaluation of tumor mutational signatures obtained from next generation techniques associated with melanoma survival. Identification of tumor expression signatures to improve the classification of patients into different prognostic groups to offer a better personalized medicine.

• Evaluation of immune response in melanoma

  Identification of polymorphisms in genes implicated in immunotolerance and immune-response that influence melanoma prognosis. Evaluation of blood immunoprofiles in skin cancer.

• Analysis of the influence of the microbiota in skin cancer

   Evaluation of the role of the gut microbiome in the modulation of immunotherapy response and melanoma outcome.

• Identification of biomarkers for melanoma

  Study of circulating free DNA (cfDNA) as a biomarker for melanoma surveillance. Study of circulating melanoma cells (CMC) and single cell sequencing.

• Development of new treatment strategies for melanoma and other skin tumors

  Research in the dermatological implications of targeted therapies in melanoma. Immunotherapy in melanoma and non-melanoma skin cancer. Development of new strategies in the treatment of the cancerization field. Inhibition of the Hedgehog pathway for the treatment of basal cell carcinomas. Photodynamic therapy for melanoma and non-melanoma skin cancer.

• Study of the mechanisms involved in carcinogenesis and photocarcinogenesis in melanoma and non-melanoma skin cancer

  Analysis of topical and oral photoprotection. Study of UV effect in skin and melanocytic nevi using imaging techniques and high-throughput molecular technologies. Investigation of somatic mutation, genomic oncogene amplification and tumor suppressor losses in melanoma. DNA repair mechanisms and their therapeutic implications.