Sònia Guedan

About me

Featured publications

• Time 2EVOLVE: predicting efficacy of engineered T-cells - how far is the bench from the bedside?

  Authors:

  Guedan, Sonia; Luu, Maik; Ammar, Delphine; Barbao, Paula; Bonini, Chiara;

  (...)

  Roberto Rodriguez-Madoz, Juan; Ruggiero, Eliana; Themeli, Maria; Hudecek, Michael; Marchiq, Ibtissam.

  See complete list of authors

  Reference: Journal For Immunotherapy Of Cancer 2022.

• An NK-like CAR T cell transition in CAR T cell dysfunction

  Authors:

  Good, Charly R; Aznar, M Angela; Kuramitsu, Shunichiro; Samareh, Parisa; Agarwal, Sangya;

  (...)

  Albelda, Steven M; Lanier, Lewis L; Young, Regina M; Berger, Shelley L; June, Carl H.

  See complete list of authors

  Reference: Cell 2021.

• Identification of cell surface targets for CAR-T cell therapies and antibody-drug conjugates in breast cancer

  Authors:

  Schettini, F; Barbao, P; Braso-Maristany, F; Galvan, P; Martinez, D;

  Pare, L; De Placido, S; Prat, A; Guedan, S.

  Reference: Esmo Open 2021.

• Single residue in CD28-costimulated CAR-T cells limits long-term persistence and antitumor durability

  Authors:

  Guedan, Sonia; Madar, Aviv; Casado-Medrano, Victoria; Shaw, Carolyn; Wing, Anna;

  Liu, Fang; Young, Regina M; June, Carl H; Posey, Avery D, Jr.

  Reference: Journal Of Clinical Investigation 2020.

• Engineering and Design of Chimeric Antigen Receptors

  Authors:

  Guedan, Sonia; Calderon, Hugo; Posey, Avery D, Jr; Maus, Marcela V;

  Reference: Molecular Therapy-Methods & Clinical Development 2019.

• Emerging Cellular Therapies for Cancer

  Authors:

  Guedan, Sonia; Ruella, Marco; June, Carl H;

  Reference: Annual Review Of Immunology 2019.

• Improving CART-Cell Therapy of Solid Tumors with Oncolytic Virus-Driven Production of a Bispecific T-cell Engager.

  Authors:

  Wing, Anna; Fajardo, Carlos Alberto; Posey, Avery D, Jr; Shaw, Carolyn; Da, Tong;

  Young, Regina M; Alemany, Ramon; June, Carl H; Guedan, Sonia.

  Reference: Cancer Immunology Research 2018.

• Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation

  Authors:

  Guedan, Sonia; Posey, Avery D, Jr; Shaw, Carolyn; Wing, Anna; Da, Tong;

  (...)

  Lacey, Simon F; Scholler, John; Keith, Brian; Young, Regina M; June, Carl H.

  See complete list of authors

  Reference: Jci Insight 2018.

• Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

  Authors:

  Kawalekar, Omkar U; O'Connor, Roddy S; Fraietta, Joseph A; Guo, Lili; McGettigan, Shannon E;

  (...)

  Keith, Brian; Snyder, Nathaniel; Blair, Ian; Milone, Michael C; June, Carl H.

  See complete list of authors

  Reference: Immunity 2016.

• Hyaluronidase Expression by an Oncolytic Adenovirus Enhances Its Intratumoral Spread and Suppresses Tumor Growth

  Authors:

  Guedan, Sonia; Jose Rojas, Juan; Gros, Alena; Mercade, Elena; Cascallo, Manel;

  Alemany, Ramon.

  Reference: Molecular Therapy 2010.

Featured Projects

• Fine-tuning T cell networks of exhaustion by synthetic sensors

  Principal investigator: Sònia Guedan Carrió

  Funder: European Commission

  Code: HORIZON-EIC-2021-Pathfinder

  Duration: 01/09/2022 - 30/08/2026

• Development of enabling technologies for T-cell immunotherapy

  Principal investigator: Sònia Guedan Carrió

  Funder: Fundación La Caixa

  Code: Health Research_2021

  Duration: 01/10/2021 - 30/09/2024

• T2EVOLVE: Accelerating Development and Improving Access to CAR and TCR-engineered T cell therapy

  Principal investigator: Sònia Guedan Carrió

  Funder: European Commission

  Code: CE_IMI12_18th_2stg

  Duration: 01/01/2021 - 31/12/2025

• CAR-T cells as drug delivery agents for the treatment of solid tumors

  Principal investigator: Sònia Guedan Carrió

  Funder: Asociación Española Contra el Cáncer

  Code: AECC_Lab20

  Duration: 01/12/2020 - 29/02/2024

• Chimeric Antigen Receptor (CAR)-modified T cells for the treatment of solid tumours

  Principal investigator: Sònia Guedan Carrió

  Funder: Agencia Estatal de Investigacion (AEI)

  Code: PID2019-109546RA-I00

  Duration: 01/06/2020 - 31/05/2023