Sònia Guedan

About me

Featured publications

• Time 2EVOLVE: predicting efficacy of engineered T-cells - how far is the bench from the bedside?

  Authors:

  Guedan, S; Luu, M; Ammar, D; Barbao, P; Bonini, C;

  (...)

  Rodriguez-Madoz, JR; Ruggiero, E; Themeli, M; Hudecek, M; Marchiq, I.

  See complete list of authors

  Reference: Journal For Immunotherapy Of Cancer 2022.

• An NK-like CAR T cell transition in CAR T cell dysfunction

  Authors:

  Good, CR; Aznar, MA; Kuramitsu, S; Samareh, P; Agarwal, S;

  (...)

  Albelda, SM; Lanier, LL; Young, RM; Berger, SL; June, CH.

  See complete list of authors

  Reference: Cell 2021.

• Identification of cell surface targets for CAR-T cell therapies and antibody-drug conjugates in breast cancer

  Authors:

  Schettini, F; Barbao, P; Brasó-Maristany, F; Galván, P; Martínez, D;

  Paré, L; De Placido, S; Prat, A; Guedan, S.

  Reference: Esmo Open 2021.

• Single residue in CD28-costimulated CAR-T cells limits long-term persistence and antitumor durability

  Authors:

  Guedan S; Madar A; Casado-Medrano V; Shaw C; Wing A;

  Liu F; Young RM; June CH; Posey AD .

  Reference: Journal Of Clinical Investigation 2020.

• Engineering and Design of Chimeric Antigen Receptors

  Authors:

  Guedan S; Calderon H; Posey AD; Maus MV ;

  Reference: Molecular Therapy-Methods & Clinical Development 2019.

• Emerging Cellular Therapies for Cancer

  Authors:

  Guedan S; Ruella M; June CH ;

  Reference: Annual Review Of Immunology 2019.

• Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation

  Authors:

  Guedan, Sonia; Posey, Avery D., Jr.; Shaw, Carolyn; Wing, Anna; Da, Tong;

  (...)

  Lacey, Simon F.; Scholler, John; Keith, Brian; Young, Regina M.; June, Carl H.;.

  See complete list of authors

  Reference: Jci Insight 2018.

• Improving CART-Cell Therapy of Solid Tumors with Oncolytic Virus-Driven Production of a Bispecific T-cell Engager.

  Authors:

  Wing A; Fajardo CA; Posey AD; Shaw C; Da T;

  Young RM; Alemany R; June CH; Guedan S .

  Reference: Cancer Immunology Research 2018.

• Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

  Authors:

  Kawalekar OU; O'Connor RS; Fraietta JA; Guo L; McGettigan SE;

  (...)

  Keith B; Snyder N; Blair I; Milone MC; June CH.

  See complete list of authors

  Reference: Immunity 2016.

• Hyaluronidase Expression by an Oncolytic Adenovirus Enhances Its Intratumoral Spread and Suppresses Tumor Growth

  Authors:

  Guedan, Sonia; Jose Rojas, Juan; Gros, Alena; Mercade, Elena; Cascallo, Manel;

  Alemany, Ramon;.

  Reference: Molecular Therapy 2010.

Featured Projects

• Fine-tuning T cell networks of exhaustion by synthetic sensors

  Principal investigator: Sònia Guedan Carrió

  Funder: European Commission

  Code: HORIZON-EIC-2021-Pathfinder

  Duration: 01/09/2022 - 30/08/2026

• Development of enabling technologies for T-cell immunotherapy

  Principal investigator: Sònia Guedan Carrió

  Funder: Fundación La Caixa

  Code: Health Research_2021

  Duration: 01/10/2021 - 30/09/2024

• T2EVOLVE: Accelerating Development and Improving Access to CAR and TCR-engineered T cell therapy

  Principal investigator: Sònia Guedan Carrió

  Funder: European Commission

  Code: CE_IMI12_18th_2stg

  Duration: 01/01/2021 - 31/12/2025

• CAR-T cells as drug delivery agents for the treatment of solid tumors

  Principal investigator: Sònia Guedan Carrió

  Funder: Asociación Española Contra el Cáncer

  Code: AECC_Lab20

  Duration: 01/12/2020 - 29/02/2024

• Chimeric Antigen Receptor (CAR)-modified T cells for the treatment of solid tumours

  Principal investigator: Sònia Guedan Carrió

  Funder: Agencia Estatal de Investigacion (AEI)

  Code: PID2019-109546RA-I00

  Duration: 01/06/2020 - 31/05/2023