Silvia Affò

About me

Featured publications

• Heterogeneity, crosstalk, and targeting of cancer-associated fibroblasts in cholangiocarcinoma

  Authors:

  Vila, PC; Ravichandra, A; Lizaso, AA; Perugorria, MJ; Affo, S;

  Reference: Hepatology 2024.

• Fibroblasts in liver cancer: functions and therapeutic translation

  Authors:

  Affo, S; Filliol, A; Gores, GJ; Schwabe, RF;

  Reference: Lancet Gastroenterology & Hepatology 2023.

• Cholangiocarcinoma - novel biological insights and therapeutic strategies

  Authors:

  Ilyas, SI; Affo, S; Goyal, L; Lamarca, A; Sapisochin, G;

  Yang, JD; Gores, GJ.

  Reference: Nature Reviews Clinical Oncology 2023.

• Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

  Authors:

  Filliol, A; Saito, Y; Nair, A; Dapito, DH; Yu, LX;

  (...)

  Zucman-Rossi, J; Karin, M; Henderson, NC; Tabas, I; Schwabe, RF.

  See complete list of authors

  Reference: Nature 2022.

• The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver

  Authors:

  Mederacke, Ingmar; Filliol, Aveline; Affo, Silvia; Nair, Ajay; Hernandez, Celine;

  (...)

  Rothlin, Carla, V; Baehre, Heike; Tabas, Ira; Sancho-Bru, Pau; Schwabe, Robert F.

  See complete list of authors

  Reference: Science Translational Medicine 2022.

• Cancer-associated fibroblasts in intrahepatic cholangiocarcinoma progression and therapeutic resistance

  Authors:

  Ravichandra A; Bhattacharjee S; Affò S ;

  Reference: Advances In Cancer Research 2022.

• Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations

  Authors:

  Affo S; Nair A; Brundu F; Ravichandra A; Bhattacharjee S;

  (...)

  Seki E; Sia D; Chen X; Califano A; Schwabe RF .

  See complete list of authors

  Reference: Cancer Cell 2021.

• The Role of Cancer-Associated Fibroblasts and Fibrosisin Liver Cancer

  Authors:

  Affo S; Yu L; Schwabe R;

  Reference: Annual Review Of Pathology-Mechanisms Of Disease 2017.

Featured Projects

• Deciphering the dynamic-plasticity and heterogeneity of cancer-associated fibroblasts (DynamHet)

  Principal investigator: Silvia Affò

  Funder: European Research Council, European Comission

  Code: FERO_JOVINV24_01

  Duration: 01/09/2024 - 01/09/2028

• Ramon y Cajal competitive Spanish program 2022 in Biomedicine.

  Principal investigator: Silvia Affò

  Funder: Ministerio de Ciencia, Innovación y Universidades

  Code: RYC2022-036321-I

  Duration: 01/07/2024 - 01/07/2029

• Investigating the interactions between heterogeneous cancer cells and the tumor microenvironment toward the development of new therapeutic strategies in cholangiocarcinoma (IntHet)

  Principal investigator: Silvia Affò

  Funder: Ministerio de Ciencia, Innovación y Universidades, Agencia Estatal de Investigación

  Code: PID2021-124694OA-100

  Duration: 01/10/2022 - 30/09/2025