Silvia Affò

About me

Featured publications

• Heterogeneity, crosstalk, and targeting of cancer-associated fibroblasts in cholangiocarcinoma

  Authors:

  Vila, Paula Cantallops; Ravichandra, Aashreya; Lizaso, Alona Agirre; Perugorria, Maria J; Affo, Silvia;

  Reference: Hepatology 2024.

• Fibroblasts in liver cancer: functions and therapeutic translation

  Authors:

  Affo, Silvia; Filliol, Aveline; Gores, Gregory J; Schwabe, Robert F;

  Reference: Lancet Gastroenterology & Hepatology 2023.

• Cholangiocarcinoma - novel biological insights and therapeutic strategies

  Authors:

  Ilyas, Sumera I; Affo, Silvia; Goyal, Lipika; Lamarca, Angela; Sapisochin, Gonzalo;

  Yang, Ju Dong; Gores, Gregory J.

  Reference: Nature Reviews Clinical Oncology 2023.

• Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

  Authors:

  Filliol, Aveline; Saito, Yoshinobu; Nair, Ajay; Dapito, Dianne H; Yu, Le-Xing;

  (...)

  Zucman-Rossi, Jessica; Karin, Michael; Henderson, Neil C; Tabas, Ira; Schwabe, Robert F.

  See complete list of authors

  Reference: Nature 2022.

• Cancer-associated fibroblasts in intrahepatic cholangiocarcinoma progression and therapeutic resistance

  Authors:

  Ravichandra, Aashreya; Bhattacharjee, Sonakshi; Affo, Silvia;

  Reference: Advances In Cancer Research 2022.

• The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver

  Authors:

  Mederacke, Ingmar; Filliol, Aveline; Affo, Silvia; Nair, Ajay; Hernandez, Celine;

  (...)

  Rothlin, Carla, V; Baehre, Heike; Tabas, Ira; Sancho-Bru, Pau; Schwabe, Robert F.

  See complete list of authors

  Reference: Science Translational Medicine 2022.

• Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations

  Authors:

  Affo, Silvia; Nair, Ajay; Brundu, Francesco; Ravichandra, Aashreya; Bhattacharjee, Sonakshi;

  (...)

  Seki, Ekihiro; Sia, Daniela; Chen, Xin; Califano, Andrea; Schwabe, Robert F.

  See complete list of authors

  Reference: Cancer Cell 2021.

• The Role of Cancer-Associated Fibroblasts and Fibrosisin Liver Cancer

  Authors:

  Affo, Silvia; Yu, Le-Xing; Schwabe, Robert F;

  Reference: Annual Review Of Pathology-Mechanisms Of Disease 2017.

Featured Projects

• Ramon y Cajal competitive Spanish program 2022 in Biomedicine.

  Principal investigator: Silvia Affò

  Funder: Ministerio de Ciencia, Innovación y Universidades

  Code: RYC2022-036321-I

  Duration: 01/07/2024 - 30/06/2029

• Deciphering the dynamic-plasticity and heterogeneity of cancer-associated fibroblasts (DynamHet)

  Principal investigator: Silvia Affò

  Funder: European Research Council, European Comission

  Code: 101077312

  Duration: 01/09/2023 - 31/08/2028

• Investigating the interactions between heterogeneous cancer cells and the tumor microenvironment toward the development of new therapeutic strategies in cholangiocarcinoma (IntHet)

  Principal investigator: Silvia Affò

  Funder: Ministerio de Ciencia, Innovación y Universidades, Agencia Estatal de Investigación

  Code: PID2021-124694OA-100

  Duration: 01/10/2022 - 30/09/2025