Ramon Trullàs
Research group
- Neurobiology Group leader (R4-IIBB-CSIC)
About me
Ramon Trullas earned his Ph.D. at the Autonomous University of Barcelona; his thesis on the mechanism of action of antidepressant drugs received a Doctorate Award. He completed postdoctoral research in the USA as a Fulbright fellow at the Laboratory for Bioorganic Chemistry, NIDDK, NIH, where he continued as an associate scientist in the Laboratory of Neuroscience. His scientific contributions include the formulation of the glutamatergic hypothesis of the mechanism of action of antidepressant drugs and; more recently, the identification of cell-free mitochondrial DNA as a biomarker of neurodegeneration. Currently, his research investigates the role of mitochondrial DNA in neurodegenerative diseases.
Featured publications
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Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis
Authors:Reference: Translational Neurodegeneration 2023. -
Molecular basis for maternal inheritance of human mitochondrial DNA
Authors:Reference: Nature Genetics 2023. -
Proteomic profiling reveals mitochondrial dysfunction in the cerebellum of transgenic mice overexpressing DYRK1A, a Down syndrome candidate gene
Authors:Reference: Frontiers In Molecular Neuroscience 2022. -
Cell-free mitochondrial DNA deletions in idiopathic, but not LRRK2 Parkinson's disease
Authors:Reference: Neurobiology Of Disease 2022. -
Cell-Free DNA as a Prognostic Biomarker for Monitoring Muscle-Invasive Bladder Cancer
Authors:Reference: International Journal Of Molecular Sciences 2022. -
Ca<sup>2+</sup>-modulated photoactivatable imaging reveals neuron-astrocyte glutamatergic circuitries within the nucleus accumbens
Authors:Reference: Nature Communications 2022. -
Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer’s disease
Authors:Reference: Molecular Neurodegeneration 2021. -
Cerebrospinal fluid mitochondrial DNA in rapid and slow progressive forms of Alzheimer’s disease
Authors:Reference: International Journal Of Molecular Sciences 2020. -
Absolute measurement of gene transcripts with Selfie-digital PCR.
Authors:Reference: Scientific Reports 2017.
Featured Projects
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Mitochondrial DNA in familial Alzheimer’s Disease
Principal investigator: Ramon Trullàs OlivaFunder: Ministerio de Ciencia e InnovaciónCode: PID2020-115091RB-I00Duration: 01/09/2021 - 31/08/2024 -
Mitochondrial DNA in prodromal Parkinson’s Disease
Principal investigator: Eduard Tolosa Sarro, Alejandro Iranzo de Riquer, Ramon Trullàs OlivaFunder: The Michael J. Fox Foundation for Parkinson's ResearchCode: MJFF-001111Duration: 01/01/2021 - 01/03/2023