Pau Sancho-Bru

Research group

Liver cell plasticity and tissue repair Group leader (R4)

psancho@recerca.clinic.cat 0000-0001-5569-9259

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Featured publications

Ductular reaction-associated neutrophils promote biliary epithelium proliferation in chronic liver disease

Authors:
Arino, Silvia; Aguilar-Bravo, Beatriz; Coll, Mar; Lee, Woo -Yong; Peiseler, Moritz;

(...)

Planas, Anna M; Gines, Pere; Moles, Anna; Kubes, Paul; Sancho-Bru, Pau.

Reference: Journal Of Hepatology 2023.
Hepatocyte dedifferentiation profiling in alcohol-related liver disease identifies CXCR4 as a driver of cell reprogramming

Authors:
Aguilar-Bravo, Beatriz; Arino, Silvia; Blaya, Delia; Pose, Elisa; de la Torre, Raquel A Martinez Garcia;

(...)

Bataller, Ramon; Lozano, Juan Jose; Gines, Pere; Mathurin, Philippe; Sancho-Bru, Pau.

Reference: Journal Of Hepatology 2023.
Ductular Reaction Promotes Intrahepatic Angiogenesis Via Slit2-Robo1 Signaling

Authors:
Coll, Mar; Arino, Silvia; Martinez-Sanchez, Celia; Garcia-Pras, Ester; Gallego, Javier;

(...)

Bataller, Ramon; Geng, Jian-Guo; Gines, Pere; Fernandez, Mercedes; Sancho-Bru, Pau.

Reference: Hepatology 2022.
Directed differentiation of human induced pluripotent stem cells to hepatic stellate cells

Authors:
Vallverdú, J; de la Torre, RMGA; Coll, M; Ariño, S; Rubio-Tomas, T;

(...)

Mannaerts, I; Verhulst, S; Smout, A; van Grunsven, LA; Verfaillie, CM.

Reference: Nature Protocols 2021.
Profiling circulating microRNAs in patients with cirrhosis and acute-on-chronic liver failure

Authors:
Blaya, D; Pose, E; Coll, M; Graupera, I; Solà, E;

(...)

Trebicka, J; Jansen, C; Castro, P; Fernandez, S; Sidorova, J.

Reference: Jhep Rep 2021.
Ductular reaction cells display an inflammatory profile and recruit neutrophils in alcoholic hepatitis

Authors:
Aguilar-Bravo, Beatriz; Rodrigo-Torres, Daniel; Arino, Silvia; Coll, Mar; Pose, Elisa;

(...)

Bataller, Ramon; Caballeria, Joan; Lozano, Juan Jose; Gines, Pere; Sancho-Bru, Pau.

Reference: Hepatology 2019.
Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis

Authors:
Coll M; Perea L; Boon R; Leite S; Vallverdú J;

(...)

Sokal E; Lozano J; van Grunsven L; Verfaillie C; Sancho-Bru P.

Reference: Cell Stem Cell 2018.

Featured Projects

Patient-derived liver biopsy-organoids for personalized medicine in NAFLD (Non-Alcoholic Fatty Liver Disease): towards real time assessment of drug response (B-ORG)

Principal investigator: Pau Sancho Bru

Funder: Ministerio de Ciencia e Innovación

Code: IBEC_ProyectCompl22

Duration: 13/04/2023 - 31/12/2024
Dissecting the role of the 14q32 region in hepatoblastoma Hblast14

Principal investigator: Pau Sancho Bru

Funder: Worldwide Cancer Research

Code: INT_WWCR_22

Duration: 01/04/2023 - 31/03/2026
Off the shelf hepatic stellate cells for liver disease modeling and drug screening

Principal investigator: Pau Sancho Bru

Funder: Instituto de Salud Carlos III

Code: FIS_DTS22

Duration: 01/01/2023 - 31/12/2025
Discovering chronic inflammation biomarkers that define key stages in the Healthy-to-NASH transition to inform early prevention and treatment strategies. (Halt-RONIN)

Principal investigator: Pau Sancho Bru

Funder: European Commission

Duration: 01/12/2022 - 30/11/2026
Mechanisms of impaired liver regeneration in alcoholic liver disease: drivers and therapeutic targets

Principal investigator: Pau Sancho Bru

Funder: Instituto de Salud Carlos III

Code: PI20/00765

Duration: 01/01/2021 - 31/12/2023

Pau Sancho-Bru

Research group

Featured publications

Ductular reaction-associated neutrophils promote biliary epithelium proliferation in chronic liver disease

Hepatocyte dedifferentiation profiling in alcohol-related liver disease identifies CXCR4 as a driver of cell reprogramming

Ductular Reaction Promotes Intrahepatic Angiogenesis Via Slit2-Robo1 Signaling

Directed differentiation of human induced pluripotent stem cells to hepatic stellate cells

Profiling circulating microRNAs in patients with cirrhosis and acute-on-chronic liver failure

Ductular reaction cells display an inflammatory profile and recruit neutrophils in alcoholic hepatitis

Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis

Featured Projects

Patient-derived liver biopsy-organoids for personalized medicine in NAFLD (Non-Alcoholic Fatty Liver Disease): towards real time assessment of drug response (B-ORG)

Dissecting the role of the 14q32 region in hepatoblastoma Hblast14

Off the shelf hepatic stellate cells for liver disease modeling and drug screening

Discovering chronic inflammation biomarkers that define key stages in the Healthy-to-NASH transition to inform early prevention and treatment strategies. (Halt-RONIN)

Mechanisms of impaired liver regeneration in alcoholic liver disease: drivers and therapeutic targets

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