Patricia Pérez-Galán

Research group

Microenvironment in lymphoma pathogenesis and therapy Group leader (R4)

pperez@recerca.clinic.cat 0000-0003-3895-5024

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Featured publications

Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target

Authors:
Dobano-Lopez, Celia; Valero, Juan Garcia; Araujo-Ayala, Ferran; Nadeu, Ferran; Gava, Fabien;

(...)

Lopez-Guillermo, Armando; Magnano, Laura; Colomer, Dolors; Bezombes, Christine; Perez-Galan, Patricia.

Reference: Blood Cancer Journal 2024.
Patient-derived lymphoma spheroids integrating immune tumor microenvironment as preclinical follicular lymphoma models for personalized medicine

Authors:
Faria, Carla; Gava, Fabien; Gravelle, Pauline; Valero, Juan Garcia; Dobano-Lopez, Celia;

(...)

Fournie, Jean-Jacques; Ysebaert, Loic; Laurent, Camille; Perez-Galan, Patricia; Bezombes, Christine.

Reference: Journal For Immunotherapy Of Cancer 2023.
A novel patient-derived 3D model recapitulates mantle cell lymphoma lymph node signaling, immune profile and in vivo ibrutinib responses

Authors:
Araujo-Ayala, Ferran; Dobano-Lopez, Celia; Valero, Juan Garcia; Nadeu, Ferran; Gava, Fabien;

(...)

Lopez-Guillermo, Armando; Gine, Eva; Colomer, Dolors; Bezombes, Christine; Perez-Galan, Patricia.

Reference: Leukemia 2023.
The receptor of the colony-stimulating factor-1 (CSF-1R) is a novel prognostic factor and therapeutic target in follicular lymphoma

Authors:
Valero, Juan Garcia; Matas-Cespedes, Alba; Arenas, Fabian; Rodriguez, Vanina; Carreras, Joaquim;

(...)

Cid, Maria C; Campo, Elias; Lopez-Guillermo, Armando; Colomer, Dolors; Perez-Galan, Patricia.

Reference: Leukemia 2021.
3D Model Characterization by 2D and 3D Imaging in t(14;18)-Positive B-NHL: Perspectives for In Vitro Drug Screens in Follicular Lymphoma

Authors:
Gava, Fabien; Faria, Carla; Gravelle, Pauline; Valero, Juan G; Dobano-Lopez, Celia;

(...)

Fournie, Jean-Jacques; Ysebaert, Loic; Laurent, Camille; Perez-Galan, Patricia; Bezombes, Christine.

Reference: Cancers 2021.
PI3Kδ inhibition reshapes follicular lymphoma-immune microenvironment cross talk and unleashes the activity of venetoclax

Authors:
Serrat, Neus; Guerrero-Hernandez, Martina; Matas-Cespedes, Alba; Yahiaoui, Anella; Valero, Juan G;

(...)

Hodson, Daniel J; Lopez-Guillermo, Armando; Colomer, Dolors; Tannheimer, Stacey; Perez-Galan, Patricia.

Reference: Blood Advances 2020.
Daratumumab displays in vitro and in vivo anti-tumor activity in models of B-cell non-Hodgkin lymphoma and improves responses to standard chemo-immunotherapy regimens

Authors:
Vidal-Crespo, Anna; Matas-Cespedes, Alba; Rodriguez, Vanina; Rossi, Cedric; Valero, Juan G;

(...)

Bezombes, Christine; van Bueren, Jeroen Lammerts; Chiu, Christopher; Doshi, Parul; Perez-Galan, Patricia.

Reference: Haematologica 2020.
The Bruton tyrosine kinase inhibitor CC-292 shows activity in mantle cell lymphoma and synergizes with lenalidomide and NIK inhibitors depending on nuclear factor-κB mutational status

Authors:
Vidal-Crespo, Anna; Rodriguez, Vanina; Matas-Cespedes, Alba; Lee, Eriong; Rivas-Delgado, Alfredo;

(...)

Lopez-Guillermo, Armando; Lopez-Guerra, Monica; Roue, GaeL; Colomer, Dolors; Perez-Galan, Patricia.

Reference: Haematologica 2017.
The Human CD38 Monoclonal Antibody Daratumumab Shows Antitumor Activity and Hampers Leukemia-Microenvironment Interactions in Chronic Lymphocytic Leukemia

Authors:
Matas-Cespedes, Alba; Vidal-Crespo, Anna; Rodriguez, Vanina; Villamor, Neus; Delgado, Julio;

(...)

Wiestner, Adrian; Parren, Paul W H I; Doshi, Parul; van Bueren, Jeroen Lammerts; Perez-Galan, Patricia.

Reference: Clinical Cancer Research 2017.
Disruption of Follicular Dendritic Cells-Follicular Lymphoma Cross-talk by the Pan-PI3K Inhibitor BKM120 (Buparlisib)

Authors:
Matas-Cespedes, Alba; Rodriguez, Vanina; Kalko, Susana G; Vidal-Crespo, Anna; Rosich, Laia;

(...)

Campo, Elias; Roue, Gael; Lopez-Guillermo, Armando; Colomer, Dolors; Perez-Galan, Patricia.

Reference: Clinical Cancer Research 2014.

Featured Projects

Red transpirenaica de terapias avanzadas en linfoma no Hodgkin (THERAVLINFO)

Principal investigator: Patricia Pérez Galán

Funder: Institut d'Investigacions Biomèdiques August Pi i Sunyer (Entidad de origen); POCTEFA-INTERREG, European Union

Code: EFA 123/1

Duration: 01/01/2024 - 31/12/2025
Characterization of duvelisib activity in follicular lymphoma and macrophages crosstalk

Principal investigator: Patricia Pérez Galán

Funder: Janssen Pharmaceuticals

Duration: 01/01/2020 - 31/12/2020
Multi-cellular interactions in the progression of chronic inflammatory diseases and lymphoproliferative disorders: 3D models to investigate targeted immune therapies -3DIMMUNETARGET

Principal investigator: Maria Cinta Cid Xutgla, Patricia Pérez Galán

Funder: Ministerio de Economia y Competitividad (MINECO)

Code: SAF 2017- 88275-R

Duration: 01/01/2018 - 31/12/2020
Cross-border network of personalized immunotherapies in Non-Hodgkin Lymphoma -IMLINFO (POCTEFA-INTERREG).

Principal investigator: Patricia Pérez Galán

Funder: INTERREG V-POCTEFA

Code: EFA281/16

Duration: 01/01/2018 - 31/12/2021
Crosstalk between lymphocytes and their microenvironment in chronic inflammatory diseases and lymphoproliferative disorders as a target for new therapeutic intervention

Principal investigator: Patricia Pérez Galán

Funder: Ministerio de Economía y Competitividad

Code: SAF 2014/57708R

Duration: 01/01/2015 - 01/01/2018

Patricia Pérez-Galán

Research group

Featured publications

Featured Projects

Red transpirenaica de terapias avanzadas en linfoma no Hodgkin (THERAVLINFO)

Characterization of duvelisib activity in follicular lymphoma and macrophages crosstalk

Multi-cellular interactions in the progression of chronic inflammatory diseases and lymphoproliferative disorders: 3D models to investigate targeted immune therapies -3DIMMUNETARGET

Cross-border network of personalized immunotherapies in Non-Hodgkin Lymphoma -IMLINFO (POCTEFA-INTERREG).

Crosstalk between lymphocytes and their microenvironment in chronic inflammatory diseases and lymphoproliferative disorders as a target for new therapeutic intervention

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