The team has studied the most common kind of breast tumour—estrogen-positive (ER +) and accounting for 80% of breast cancer tumour cases—that is characterised by a long period of latency with no symptoms. The study has been published today in Nature Cell Biology.
MSK1, the protein that keeps tumour cells dormant
The team has identified the protein kinase MSK1 as a key regulator of dormant or latent metastases. Using clinical samples from patients, the scientists have confirmed that ER + breast cancer tumours that do not express MSK1 are associated with a risk of earlier relapse, while those that express this molecule will form metastases later.
“We are interested in understanding the mechanisms underlying metastasis and the time component of this process. Until now, little was known in preclinical models about the mechanisms that allow breast cancer cells to leave the latent state and even less is known in patients," explains Roger Gomis, head of the Growth Control and Cancer Metastasis Lab.
The researchers believe that in the future this discovery may benefit patients in two ways. Firstly, it will help to identify those with an imminent risk of relapse and to adjust the treatment for this prognosis. Secondly, attempts could be made to design a treatment to mimic the function of MSK1 kinase, with the aim to maintain metastatic lesions in a latent and asymptomatic state for as long as possible.
The study was done in collaboration with the labs headed by Salvador Aznar Benitah and Angel R. Nebreda, both members of IRB Barcelona’s Oncology Programme, and with the labs led by Violeta Serra, at the Vall d’Hebrón Institute of Oncology (VHIO) and Joan Albanell, at the Hospital del Mar. The first author of the article is Sylvia Gawrzak, a former "la Caixa" PhD student at IRB Barcelona who is currently doing a postdoc in EMBL, Heidelberg, Germany. From the Clínic-IDIBAPS have also participated Montse Muñoz, oncologist specialized in breast cancer, and Juan Miguel Cejalvo, PhD researcher of the PhD4MD program at IDIBAPS and IRB Barcelona.
The study was funded by the Minstry of Economy and Competitiveness through ERDFs, the Generalitat de Catalunya through AGAUR, BBVA Foundation, Worldwide Cancer Research and the Centro de Investigación Biomédica en Red de Oncología (CIBERONC) (Biomedical Research Networking Centre in Oncology), in which the researcher Roger Gomis participates.
Article of reference:
MSK1 regulates luminal cell differentiation and metastatic dormancy in breast cancer
Sylwia Gawrzak, Lorenzo Rinaldi, Enrique J. Arenas, Fernando Salvador, Sara Gregorio, Federico Rojo, Ivan del Barco Barrantes, Juan Miguel Cejalvo, Marta Palafox, Marc Guiu, Antonio Berenguer-Llergo, Aikaterini Symeonidi, Jelena Urosevic, Anna Bellmunt, Daniela Kalafatovic, Anna Arnal-Estapé, Esther Fernández, Barbara Müllauer, Rianne Groeneveld, Konstantin Slobodnyuk, Camille Stephan-Otto Attolini,Cristina Saura, Joaquín Arribas, Javier Cortes, Ana Rovira, Montse Muñoz, Ana Lluch, Violeta Serra, Joan Albanell, Aleix Prat, Angel R. Nebreda, Salvador Aznar-Benitah & Roger R. Gomis
Nature Cell Biology (2018) doi: 10.1038/s41556-017-0021-z
Source: IRBB Barcelona