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Metabolism and disease programme (MetaDis): a multidisciplinary approach to understanding metabolic diseases

Description

Metabolic diseases, such as obesity, diabetes and cardiovascular diseases, pose one of the main challenges to public health and have serious socioeconomic implications. These diseases involve many different organs and systems, which makes a multidisciplinary approach essential to understand their pathogenesis in a comprehensive and global way. MetaDis was created to address these challenges from a holistic perspective to promote more effective prevention and management.

MetaDis aims to decipher the mechanisms underlying metabolic diseases through molecular and systemic studies, analyse interactions between organs and perform patient-focused trials. It also seeks to determine the impact of factors such as nutrition, exercise, microbiota and ageing to provide a global understanding of these diseases.

Goals

  • Deciphering pathogenic mechanisms. This includes understanding the mechanisms responsible for metabolic diseases, identifying key interactions between the organs involved and discovering new biomarkers and therapeutic targets. All data generated will be shared through a public platform, facilitating their access and use for the scientific community.
  • Study of determinant factors. MetaDis will analyse how diet, exercise, microbiota and ageing influence the progression of metabolic diseases. The programme will also investigate the role of the circadian rhythm in modulating ageing and in the development of age-related diseases.
  • Develop innovative methodologies and new therapeutic approaches. MetaDis will create patient-derived models and murine models that accurately replicate human metabolic diseases. It also aims to make progress in personalised treatments and explore drug repurposing for potential new indications.

This comprehensive approach will allow MetaDis to make headway in our understanding and treatment of metabolic diseases, offering innovative and effective solutions for a problem with great social impact.

Coordinators

Mercedes Fernández-Lobato
COORDINATOR
Josep Vidal
CO-COORDINATOR

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