Lymphoid neoplasms programme
Description
Lymphoid neoplasms are haematological cancers derived from lymphocytes, a type of white blood cell, at different stages of development. These diseases are very heterogeneous, which greatly complicates research in this field. Lymphoid neoplasms notably include lymphomas and acute and chronic leukaemias of lymphoid origin. Clinical and biological knowledge of these entities has increased enormously over the last few decades, with very significant improvements in the diagnosis and treatment of patients and, therefore, in their prognosis.
The programme is made up of eight IDIBAPS groups interested in different aspects of lymphoid tumours, and aims to broaden the knowledge of these diseases in order to improve patient care in three areas: improving diagnostic tools, better defining patient prognosis, and developing new therapeutic approaches such as the identification of new target molecules and the development of immunotherapies and cell therapies.
Goals
- To generate "multi-omic” data, in other words genomic, transcriptomic, epigenomic and proteomic data, and to characterize the single-cell state landscape of lymphomas and other lymphoproliferative disorders.
- To define the molecular mechanisms involved in the pathogenesis of these diseases, both the characteristics of tumour cells and their interaction with surrounding cells.
- To develop ex vivo models derived from patients in order to design personalized treatment.
- To transfer the knowledge generated to clinical practice (diagnosis, prognosis and treatment).
Coordinators
Groups
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Lymphoid neoplasms
Armando López-Guillermo -
Biomedical epigenomics
José Ignacio Martín-Subero -
Molecular pathology of lymphoid neoplasms
Elías Campo -
Experimental therapies in lymphoid neoplasms
Dolors Colomer -
Microenvironment in lymphoma pathogenesis and therapy
Patricia Pérez-Galán -
Molecular genetics of paediatric lymphomas
Itziar Salaverria -
Systemic vasculitis
Maria Cinta Cid