Research lines

• 1. Inflammation of the upper and lower respiratory mucosa

  Mechanisms involved in sinonasal and bronchial development, inflammation, and remodeling.

• 2. Sense of smell in health and disease

  Mechanisms involved in olfactory dysfunction (rhinitis, rhinosinusitis, septal perforation) and neurogenesis of sinonasal diseases, traumatic brain injury, and neurodegenerative (Parkinson) diseases (cell and animal models).

• 3. Food and drug allergy

  Genetic, immunological, and biochemical mechanisms of respiratory, food, and drug allergy.

• 4. Glucocorticoid resistance

  Mechanisms and biomarkers involved in glucocorticoid resistance of respiratory and non-respiratory diseases.

• 5. Aspirin and Non-Steroidal Anti-inflammatory Drug (NSAID) intolerance

  Mechanisms of allergy and co-factors, regulation of cyclooxygenase, leukotriene, and prostaglandins (PGE2) and their receptors.

• 6. Pathophysiology of eosinophils, mast cells, and basophils

  Anaphylactic reactions (mastocytosis, adapter molecules in the signaling of IgE). Antiinflammatory drug effect in eosinophils and epithelial cells (corticosteroids, MP-AzeFlu, anti-PAF), and mast cell and basophils (omalizumab).

• 7. Skull base tumours

  Impact of skull base tumours in quality of life and olfaction. Different surgical approaches.