Research lines

• 1. Epidemiology, prevention and new treatments of pneumonias associated with artificial ventilation and new methods of fast diagnosis

  Risk factors, Resistances of microorganisms. Local and systemic inflammatory response. New therapies.

• 2. Epidemiology and diagnosis of community-acquired pneumonia

  Multicenter studies in the setting of community-acquired pneumonia. New methods for fast diagnosis. New treatments. Resistances of microorganisms. Local and systemic inflammatory response. S. pneumoniae in the context of new vaccines.

• 3. Etiopathogenesis, bronchial infection and inflammation in the patient with chronic obstructive pulmonary disease (COPD

  Role of infections in exacerbation of the disease. Study of bronchial and associated systemic response. Analysis of the risk and prognostic factors in acute episodes. Smoking. Epidemiology and diagnosis of alpha-1-antitrypsin deficiency.

• 4. Chronic pulmonary infections

  Bronchiectasis not associated with cystic fibrosis, immune deficiencies and cystic fibrosis in the adult. Control of bronchial colonization. Study of bronchial inflammatory and associated systemic response. New treatment modalities (nebulizer antibiotic treatment). Replacement therapy with immunoglobulins.

• 5. Infectious lung complications in immune depressed patients

  Evaluation of the etiological factors. Optimization of the diagnostic techniques. Study of bronchial inflammatory and associated systemic response. Analysis of prognostic factors.

• 6. Invasive and noninvasive mechanical ventilation

  Epidemiology, costeffectiveness and physiopathology. New techniques. Weaning from mechanical ventilation: role of the inflammatory response and respiratory failure following extubation.

• 7. Porcine model of acute pulmonary damage due to methicillinresistant P. aeruginosa, S. aureus and S. pneumoniae

  Study of new coadjuvant drugs, antibiotics and therapies for pneumonia, prevention of ventilator-associated pneumonia (VAP), and new forms of mechanical ventilation, acute lung injury, study of the pharmacokinetics of antibiotics and other drugs.

• 8. Translational research laboratory for the microbiology diagnosis and pathogen-host response in respiratory infections

  Respiratory microbiome, advanced and rapid microbiology diagnostic, biofilm associated acute and chronic respiratory infections, advanced imaging in vivo, biomarkers, transcriptomics, molecular biology and a cellular model of immunomodulation for host-pathogen response.

• 9. Chronic sleep apnea

  • Chronic sleep apnea models
  • Multicenter Study to assess the effect of CPAP on cardiovascular diseases in patients with sleep apnea
  • Telematic control of CPAP treatment in sleep apnea syndrome