Featured publications

Immune translational control by CPEB4 regulates intestinal inflammation resolution and colorectal cancer development

Sibilio, A; Suñner, C; Fernández-Alfara, M; Martín, J; Berenguer, A;

(...)

Millanes-Romero, A; Fernández-Miranda, G; Batlle, E; Méndez, R; Fernández, M.

Reference:
Iscience 2022.
Targeting the cytoplasmic polyadenylation element-binding protein CPEB4 protects against diet-induced obesity and microbiome dysbiosis

Pell, Nuria; Garcia-Pras, Ester; Gallego, Javier; Naranjo-Suarez, Salvador; Balvey, Alexandra;

(...)

Schierwagen, Robert; Rheinwalt, Karl P; Trebicka, Jonel; Mendez, Raul; Fernandez, Mercedes.

Reference:
Molecular Metabolism 2021.
Metabolic Reprogramming of Liver Fibrosis

Delgado, M Eugenia; Cardenas, Beatriz I; Farran, Nuria; Fernandez, Mercedes;

Reference:
Cells 2021.
Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes

Riechert, E; Kmietczyk, V; Jürgensen, L; Kamuf-Schenk, V; Varma, E;

(...)

Hentze, MW; Martin, J; Méndez, R; Ramirez-Pedraza, M; Fernandez, M.

Reference:
Cell Reports 2021.
CPEB4 Increases Expression of PFKFB3 to Induce Glycolysis and Activate Mouse and Human Hepatic Stellate Cells, Promoting Liver Fibrosis

Mejias, Marc; Gallego, Javier; Naranjo-Suarez, Salvador; Ramirez, Marta; Pell, Nuria;

Manzano, Anna; Suner, Clara; Bartrons, Ramon; Mendez, Raul; Fernandez, Mercedes.

Reference:
Gastroenterology 2020.
Role and therapeutic potential of vascular stem/progenitor cells in pathological neovascularisation during chronic portal hypertension

Garcia-Pras, Ester; Gallego, Javier; Coch, Laura; Mejias, Marc; Fernandez-Miranda, Gonzalo;

Pardal, Ricardo; Bosch, Jaime; Mendez, Raul; Fernandez, Mercedes.

Reference:
Gut 2017.
Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress

Maillo, Carlos; Martin, Judit; Sebastian, David; Hernandez-Alvarez, Maribel; Garcia-Rocha, Mar;

Reina, Oscar; Zorzano, Antonio; Fernandez, Mercedes; Mendez, Raul.

Reference:
Nature Cell Biology 2017.
Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease

Calderone, Vittorio; Gallego, Javier; Fernandez-Miranda, Gonzalo; Garcia-Pras, Ester; Maillo, Carlos;

(...)

Graupera, Mariona; Navarro, Pilar; Bosch, Jaime; Fernandez, Mercedes; Mendez, Raul.

Reference:
Gastroenterology 2016.
Antiangiogenic and antifibrogenic activity of pigment epithelium-derived factor (PEDF) in bile duct-ligated portal hypertensive rats

Mejias, Marc; Coch, Laura; Berzigotti, Annalisa; Garcia-Pras, Ester; Gallego, Javier;

Bosch, Jaime; Fernandez, Mercedes.

Reference:
Gut 2015.
Disruption of negative feedback loop between vasohibin-1 and VEGF decreases portal pressure, angiogenesis and fibrosis in cirrhotic rats

Coch, Laura; Mejias, Marc; Berzigotti, Annalisa; Garcia-Pras, Ester; Gallego, Javier;

Bosch, Jaime; Mendez, Raul; Fernandez, Mercedes.

Reference:
Hepatology 2014.