Translational control of liver disease and cancer
Featured publications
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Immune translational control by CPEB4 regulates intestinal inflammation resolution and colorectal cancer development
Sibilio, A; Suñner, C; Fernández-Alfara, M; Martín, J; Berenguer, A;(...)Millanes-Romero, A; Fernández-Miranda, G; Batlle, E; Fernández, M; Méndez, R.Reference:Iscience 2022.
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Targeting the cytoplasmic polyadenylation element-binding protein CPEB4 protects against diet-induced obesity and microbiome dysbiosis
Pell, N; Garcia-Pras, E; Gallego, J; Naranjo-Suarez, S; Balvey, A;(...)Schierwagen, R; Rheinwalt, KP; Trebicka, J; Mendez, R; Fernandez, M.Reference:Molecular Metabolism 2021.
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Metabolic Reprogramming of Liver Fibrosis
Delgado, ME; Cardenas, BI; Farran, N; Fernandez, M;Reference:Cells 2021.
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Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes
Riechert, E; Kmietczyk, V; Stein, F; Schwarzl, T; Sekaran, T;(...)Doroudgar, S; Méndez, R; Katus, HA; Hentze, MW; Völkers, M.Reference:Cell Reports 2021.
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CPEB4 Increases Expression of PFKFB3 to Induce Glycolysis and Activate Mouse and Human Hepatic Stellate Cells, Promoting Liver Fibrosis
Mejias M; Gallego J; Naranjo-Suarez S; Ramirez M; Pell N;Manzano A; Suñer C; Bartrons R; Mendez R; Fernandez M .Reference:Gastroenterology 2020.
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Role and therapeutic potential of vascular stem/progenitor cells in pathological neovascularisation during chronic portal hypertension
Garcia-Pras, Ester; Gallego, Javier; Coch, Laura; Mejias, Marc; Fernandez-Miranda, Gonzalo;Pardal, Ricardo; Bosch, Jaime; Mendez, Raul; Fernandez, Mercedes.Reference:Gut 2017.
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Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress
Maillo, Carlos; Martin, Judit; Sebastian, David; Hernandez-Alvarez, Maribel; Garcia-Rocha, Mar;Reina, Oscar; Zorzano, Antonio; Fernandez, Mercedes; Mendez, Raul.Reference:Nature Cell Biology 2017.
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Sequential Functions of CPEB1 and CPEB4 Regulate Pathologic Expression of Vascular Endothelial Growth Factor and Angiogenesis in Chronic Liver Disease
Calderone, Vittorio; Gallego, Javier; Fernandez-Miranda, Gonzalo; Garcia-Pras, Ester; Maillo, Carlos;(...)Graupera, Mariona; Navarro, Pilar; Bosch, Jaime; Fernandez, Mercedes; Mendez, Raul.Reference:Gastroenterology 2016.
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Antiangiogenic and antifibrogenic activity of pigment epithelium-derived factor (PEDF) in bile duct-ligated portal hypertensive rats
Mejias, Marc; Coch, Laura; Berzigotti, Annalisa; Garcia-Pras, Ester; Gallego, Javier;Bosch, Jaime; Fernandez, Mercedes.Reference:Gut 2015.
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Disruption of negative feedback loop between vasohibin-1 and VEGF decreases portal pressure, angiogenesis and fibrosis in cirrhotic rats
Coch, Laura; Mejias, Marc; Berzigotti, Annalisa; Garcia-Pras, Ester; Gallego, Javier;Bosch, Jaime; Mendez, Raul; Fernandez, Mercedes.Reference:Hepatology 2014.