Featured publications

• Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration

  Ballasch, I; García-García, E; Vila, C; Pérez-González, A; Sancho-Balsells, A;

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  Gasull, X; Alberch, J; Rodríguez, MJ; Canals, JM; Giralt, A.

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  Reference:

  Brain Behavior And Immunity 2023.

• GPC3-Unc5 receptor complex structure and role in cell migration

  Akkermans, Onno; Delloye-Bourgeois, Celine; Peregrina, Claudia; Carrasquero-Ordaz, Maria; Kokolaki, Maria;

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  Owens, Raymond J; Robinson, Carol V; Castellani, Valerie; del Toro, Daniel; Seiradake, Elena.

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  Reference:

  Cell 2022.

• Altered m6A RNA methylation contributes to hippocampal memory deficits in Huntington's disease mice

  Pupak, A; Singh, A; Sancho-Balsells, A; Alcalá-Vida, R; Espina, M;

  Giralt, A; Martí, E; Orom, UAV; Ginés, S; Brito, V.

  Reference:

  Cellular And Molecular Life Sciences 2022.

• Translating cell therapies for neurodegenerative diseases: Huntington's disease as a model disorder

  Rosser, AE; Busse, ME; Gray, WP; Badin, RA; Perrier, AL;

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  Mills, LJ; Drew, C; Goldman, SA; Canals, JM; Thompson, LM.

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  Reference:

  Brain 2022.

• Huntington’s disease brain-derived small RNAs recapitulate associated neuropathology in mice

  Creus-Muncunill, J; Guisado-Corcoll, A; Venturi, V; Pantano, L; Escaramís, G;

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  Masana, M; Llorens, F; Diaz-Lucena, D; Pérez-Navarro, E; Martí, E.

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  Reference:

  Acta Neuropathologica 2021.

• Neuron type-specific increase in lamin B1 contributes to nuclear dysfunction in Huntington's disease

  Alcalá-Vida, R; Garcia-Forn, M; Castany-Pladevall, C; Creus-Muncunill, J; Ito, Y;

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  Samarajiwa, S; Peiró, S; Di Croce, L; Narita, M; Pérez-Navarro, E.

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  Reference:

  Embo Molecular Medicine 2021.

• M2 cortex-dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington's disease

  Fernandez-Garcia, Sara; Conde-Berriozabal, Sara; Garcia-Garcia, Esther; Gort-Paniello, Clara; Bernal-Casas, David;

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  Campa, Leticia; Artigas, Francesc; Jose Rodriguez, Manuel; Alberch, Jordi; Masana, Merce.

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  Reference:

  Elife 2020.

• Increased translation as a novel pathogenic mechanism in Huntington's disease

  Creus-Muncunill J; Badillos-Rodríguez R; Garcia-Forn M; Masana M; Barriga G;

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  Alberch J; Malagelada C; Delgado-García J; Gruart A; Pérez-Navarro E.

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  Reference:

  Brain 2019.

• Cyclin-Dependent Kinase 5 Dysfunction Contributes to Depressive-like Behaviors in Huntington's Disease by Altering the DARPP-32 Phosphorylation Status in the Nucleus Accumbens

  Brito V; Giralt A; Masana M; Royes A; Espina M;

  Sieiro E; Alberch J; Castañé A; Girault J; Ginés S.

  Reference:

  Biological Psychiatry 2019.

• Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation.

  Cariulo C; Azzollini L; Verani M; Martufi P; Boggio R;

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  Santimone I; Squitieri F; Lashuel HA; Petricca L; Caricasole A .

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  Reference:

  Proceedings Of The National Academy Of Sciences Of The United States Of America 2017.