Featured publications

• Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration

  Ballasch, I; García-García, E; Pérez-González, A; Sancho-Balsells, A; Fernández, J;

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  Alberch, J; Rodríguez, MJ; Giralt, A; Vila, C; Canals, JM.

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  Reference:

  Brain Behavior And Immunity 2023.

• GPC3-Unc5 receptor complex structure and role in cell migration

  Akkermans, Onno; Delloye-Bourgeois, Celine; Peregrina, Claudia; Carrasquero-Ordaz, Maria; Kokolaki, Maria;

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  Robinson, Carol V; Robinson, Carol V; Castellani, Valerie; del Toro, Daniel; Seiradake, Elena.

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  Reference:

  Cell 2022.

• Altered m6A RNA methylation contributes to hippocampal memory deficits in Huntington's disease mice

  Pupak, A; Sancho-Balsells, A; Espina, M; Giralt, A; Martí, E;

  Ginés, S; Brito, V; Singh, A; Orom, UAV; Alcalá-Vida, R.

  Reference:

  Cellular And Molecular Life Sciences 2022.

• Translating cell therapies for neurodegenerative diseases: Huntington's disease as a model disorder

  Rosser, AE; Gray, WP; Busse, ME; Mills, LJ; Drew, C;

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  Martin, UP; Salado-Manzano, C; Canals, JM; Goldman, SA; Thompson, LM.

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  Reference:

  Brain 2022.

• Huntington’s disease brain-derived small RNAs recapitulate associated neuropathology in mice

  Creus-Muncunill, J; Guisado-Corcoll, A; Escaramís, G; de Herreros, MG; Solaguren-Beascoa, M;

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  Llorens, F; Diaz-Lucena, D; Venturi, V; Navarrete, C; Pantano, L.

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  Reference:

  Acta Neuropathologica 2021.

• Neuron type-specific increase in lamin B1 contributes to nuclear dysfunction in Huntington's disease

  Alcalá-Vida, R; Garcia-Forn, M; Castany-Pladevall, C; Creus-Muncunill, J; Ito, Y;

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  Samarajiwa, S; Peiró, S; Di Croce, L; Narita, M; Pérez-Navarro, E.

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  Reference:

  Embo Molecular Medicine 2021.

• M2 cortex-dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington's disease

  Fernandez-Garcia, Sara; Conde-Berriozabal, Sara; Garcia-Garcia, Esther; Gort-Paniello, Clara; Bernal-Casas, David;

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  Campa, Leticia; Artigas, Francesc; Jose Rodriguez, Manuel; Alberch, Jordi; Masana, Merce.

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  Reference:

  Elife 2020.

• Increased translation as a novel pathogenic mechanism in Huntington's disease

  Creus-Muncunill, Jordi; Badillos-Rodriguez, Raquel; Garcia-Forn, Marta; Masana, Merce; Garcia-Diaz Barriga, Gerardo;

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  Alberch, Jordi; Malagelada, Cristina; Delgado-Garcia, Jose M; Gruart, Agnes; Perez-Navarro, Esther.

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  Reference:

  Brain 2019.

• Cyclin-Dependent Kinase 5 Dysfunction Contributes to Depressive-like Behaviors in Huntington's Disease by Altering the DARPP-32 Phosphorylation Status in the Nucleus Accumbens

  Brito, Veronica; Giralt, Albert; Masana, Merce; Royes, Aida; Espina, Marc;

  Sieiro, Esther; Alberch, Jordi; Castane, Anna; Girault, Jean-Antoine; Gines, Silvia.

  Reference:

  Biological Psychiatry 2019.

• Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation.

  Cariulo C; Azzollini L; Verani M; Martufi P; Boggio R;

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  Santimone I; Squitieri F; Lashuel HA; Petricca L; Caricasole A .

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  Reference:

  Proceedings Of The National Academy Of Sciences Of The United States Of America 2017.