Inflammatory joint diseases (IJDs)
Research lines
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Prognostic factors in early arthritis
- Prognostic factors (clinical and immunogenetic) in patients with recent-onset rheumatoid arthritis.
- Production of new synthetic citrullinated and carbamylated peptides for the design of immunoassays with diagnostic and prognostic value in recent-onset rheumatoid arthritis and palindromic rheumatism.
- Randomized clinical trial : Effects of abatacept on the progression to rheumatoid arthritis in patients with palindromic rheumatism (PALABA study). EudractCT: 2017-004543-20
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Clinical and sonographic characterization of clinical remission
- Definition and clinical characterization of subclinical 'active synovitis'
- Immunopathological and molecular characterization of subclinical 'active synovitis'
- Research of biomarkers of clinical reactivation and radiographic progression
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Immunopathology of synovitis in chronic arthritis
- Utility in pathogenesis, differential diagnosis and prognosis of rheumatoid arthritis and psoriatic arthritis. Immunopathological changes induced by biological treatments. Mechanism of action of targeted therapies. Synovial response biomarkers.
- We are collaborating as Spanish Reference Center in synovial immunopathology in two strategic clinical trials based in stratification of patients according the enrichment o B-cells in synovial membrane. Centers around UK and Europe are participating in these pioneering clinical trials very relevant to achieve a personalized medicine.
- Randomised open labelled study in anti-TNFα inadequate responders to investigate the mechanisms of Response – Resistance to Rituximab versus Tocilizumab in RA (R4-RA Trial). IP: Prof. C. Pitzalis, Queen Mary University of London, London, UK)
- Randomised open labelled study in Metrotexate inadequate responders to investigate the mechanisms of Response – Resistance to Etanercept versus Rituximab versus Tocilizumab in RA (STRAP-EU Trial)
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Pharmacogenomics of chronic arthritis
- Genetic biomarkers associated with biological therapy response in rheumatoid arthritis and psoriatic arthritis
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The gut-joint axis in rheumatoid arthritis patients: role of microbiota-induced intestinal T follicular helper cells and innate immune cells in the pathogenesis of the disease
- Collaboration with F. Ciccia (Naples University) and G. Schett (Erlangën University) to know the interaction and physiopathological relevance of the gut-joint interaction