Líneas de investigación

• The multifaceted mitochondria: obesity, diabetes and beyond

  Directed by Marc Claret 

  We have several projects aimed at understanding neuron-type specific mitochondrial biology, from many different angles (dynamics, neurosteroid production, reactive oxygen species release, proteostasis, etc.), and its impact in systemic metabolism and cognitive function.  

• Cell-type specific epigenetics and obesity

  Directed by Marc Claret 

  We use cutting-edge genetic models to unravel the epigenetic landscape of specific subpopulations of neurons under obesogenic conditions and other detrimental environmental stimuli. 

• Endothelial cells: new players in metabolic disorders

  Directed by Marc Claret 

  We are also interested in understanding the influence of endothelial cells in systemic metabolic control and in the development of obesity and diabetes.  

• Neuronal Heterogeneity and Functional Specialization

  Directed by Marc Claret 

  Our research focuses on understanding how neuronal heterogeneity within key hypothalamic circuits contributes to the precise regulation of metabolism. Using intersectional genetics and advanced neurobiological tools, we dissect distinct neuronal subpopulations to uncover their unique roles in energy balance, glucose homeostasis, and adaptive metabolic responses. This approach allows us to map functional diversity at a cellular level, revealing how specific neuronal identities translate into differential control of metabolic processes. 

• Feeding Behavior, Stress, Social Behavior, and Emotions

  Directed by Marc Claret 

  We have an original line of research exploring the complex interplay between feeding behavior, stress, emotions, and social interactions. Our work investigates how these factors influence appetitive behaviors and how disruptions in one domain can affect overall metabolic and psychological well-being. 

• Neuroplasticity of the female brain

  Directed by Roberta Haddad Tovolli 

  We are applying advanced neurobiological tools to understand the neuronal mechanisms underlying changes in feeding and maternal behaviours, with a particular focus on pregnancy and lactation. 

• Maternal programming

  Directed by Roberta Haddad Tovolli 

  Our research investigates how maternal eating habits, including obesogenic diets and altered feeding behaviors driven by female-specific emotional and motivational states during pregnancy, rewire neuronal circuits and influence the metabolic and neuropsychiatric health of the offspring.