Marc Claret

Research group

Neuronal control of metabolism (NeuCoMe) Group leader (R4)

mclaret@recerca.clinic.cat 0000-0001-7766-9296

Featured publications

POMC neuronal heterogeneity in energy balance and beyond: an integrated view

Authors:
Quarta, C; Claret, M; Zeltser, LM; Williams, KW; Yeo, GSH;

Tschöp, MH; Diano, S; Brüning, JC; Cota, D.

Reference: Nature Metabolism 2021.
p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1

Authors:
Quiñones M; Al-Massadi O; Folgueira C; Bremser S; Gallego R;

(...)

López M; Claret M; Kloppenburg P; Sabio G; Nogueiras R.

Reference: Nature Communications 2018.
Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.

Authors:
Ramirez, Sara; Gomez-Valades, Alicia G; Schneeberger, Marc; Varela, Luis; Haddad-Tovolli, Roberta;

(...)

Servitja, Joan-Marc; Horvath, Tamas L; Gomis, Ramon; Zorzano, Antonio; Claret, Marc.

Reference: Cell Metabolism 2017.
Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice

Authors:
Schneeberger, Marc; Everard, Amandine; Gomez-Valades, Alicia G; Matamoros, Sebastien; Ramirez, Sara;

Delzenne, Nathalie M; Gomis, Ramon; Claret, Marc; Cani, Patrice D.

Reference: Scientific Reports 2015.
Reduced α-MSH Underlies Hypothalamic ER-Stress-Induced Hepatic Gluconeogenesis

Authors:
Schneeberger, Marc; Gomez-Valades, Alicia G; Altirriba, Jordi; Sebastian, David; Ramirez, Sara;

(...)

Jones, John G; Manadas, Bruno; Zorzano, Antonio; Gomis, Ramon; Claret, Marc.

Reference: Cell Reports 2015.
Hypothalamic and brainstem neurocircuitries controlling homeostatic energy balance

Authors:
Schneeberger, Marc; Gomis, Ramon; Claret, Marc;

Reference: Journal Of Endocrinology 2014.
Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance

Authors:
Schneeberger, Marc; Dietrich, Marcelo O; Sebastian, David; Imbernon, Monica; Castano, Carlos;

(...)

Gomis, Ramon; Nogueiras, Ruben; Horvath, Tamas L; Zorzano, Antonio; Claret, Marc.

Reference: Cell 2013.
Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesity

Authors:
Claret; Marc;

Reference: Molecular Metabolism 2013.
Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice

Authors:
Claret, Marc; Smith, Mark A; Knauf, Claude; Al-Qassab, Hind; Woods, Angela;

(...)

Ashworth, Alan; Burcelin, Remy; Ashford, Michael L; Carling, David; Withers, Dominic J.

Reference: Diabetes 2011.
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons.

Authors:
Claret M; Smith MA; Batterham RL; Selman C; Choudhury AI;

(...)

Viollet B; Vaulont S; Ashford ML; Carling D; Withers DJ .

Reference: Journal Of Clinical Investigation 2007.

Featured Projects

Hypothalamic control of gut function and microbiota composition: implications for energy balance regulation (NeuroGut)

Principal investigator: Marc Claret Carles

Funder: CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER (Sede o evento); La Caixa

Code: HR18-00100

Duration: 01/11/2019 - 31/10/2022
Mitochondrial fusion in endothelial cells: impact on systemic energy and glucose homeostasis

Principal investigator: Marc Claret Carles

Funder: CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER (Sede o evento); European Foundation for the Study of Diabetes (EFSD)

Code: EFSD/NOVO_17_01

Duration: 15/02/2018 - 14/02/2020
Decoding mitochondrial nutrient-sensing programs in POMC neurons as key determinants of metabolic health (MITOSENSING)

Principal investigator: Marc Claret Carles

Funder: CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER (Sede o evento); European Research Council (ERC) ; Institut d'Investigacions Biomèdiques August Pi i Sunyer (Entidad de origen)

Code: 725004

Duration: 01/04/2017 - 31/03/2022

Web: https://cordis.europa.eu/project/id/725004
Investigating the role of hypothalamic POMC neuron-derived neurosteroids as critical regulators of energy balance and metabolism

Principal investigator: Marc Claret Carles

Funder: CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER (Sede o evento); Instituto de Salud Carlos III (ISCIII)

Code: PI16/00963

Duration: 01/01/2017 - 31/12/2019
Estudio del papel de la fusión mitocondrial en neuronas hipotalámicas sobre el control del apetito y la regulación del peso corporal: Opa 1 como potencial diana terapéutica para el tratamiento de la obesidad

Principal investigator: Marc Claret Carles

Funder: CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER (Sede o evento); Fundación BBVA

Code: BBM-MED-1172

Duration: 11/11/2015 - 31/01/2018

Marc Claret

Research group

Featured publications

Featured Projects

Hypothalamic control of gut function and microbiota composition: implications for energy balance regulation (NeuroGut)

Mitochondrial fusion in endothelial cells: impact on systemic energy and glucose homeostasis

Decoding mitochondrial nutrient-sensing programs in POMC neurons as key determinants of metabolic health (MITOSENSING)

Investigating the role of hypothalamic POMC neuron-derived neurosteroids as critical regulators of energy balance and metabolism

Estudio del papel de la fusión mitocondrial en neuronas hipotalámicas sobre el control del apetito y la regulación del peso corporal: Opa 1 como potencial diana terapéutica para el tratamiento de la obesidad

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