Azucena Salas
Research group
- Inflammatory bowel disease Group leader (R4)
About me
As a researcher, I have been devoted to biomedical science and to inflammatory mechanisms for +20 years. After a postdoctoral fellowship at Harvard Medical School, I became an independent researcher in 2005. Since 2009, I hold a permanent position at IDIBAPS, Hospital Clinic. Currently, I lead the IBD translational lab at IDIBAPS, focusing on the immune regulation disruption in IBD patients, identifying new targets and developing therapies. We collaborate with pharma companies and conduct sub-studies in clinical trials. Besides teaching, I’m an Immunology Associate Professor at the University of Barcelona (2009). My purpose is to carry out research that can directly impact patients’ lives.
Featured publications
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Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease
Authors:Reference: Nature Communications 2023. -
IL-12 and IL-23 pathway inhibition in inflammatory bowel disease
Authors:Reference: Nature Reviews Gastroenterology & Hepatology 2023. -
Generation of human colon organoids from healthy and inflammatory bowel disease mucosa
Authors:Reference: Plos One 2022. -
Dissecting common and unique effects of anti-α4β7 and anti-tumor necrosis factor treatment in ulcerative colitis
Authors:Reference: Journal Of Crohns & Colitis 2021. -
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease
Authors:Reference: Nature Reviews Gastroenterology & Hepatology 2020. -
Differences in peripheral and tissue immune cell populations following hematopoietic stem cell transplantation in Crohn's disease patients
Authors:Reference: Journal Of Crohns & Colitis 2019. -
Alterations in the epithelial stem cell compartment could contribute to permanent changes in the mucosa of patients with ulcerative colitis
Authors:Reference: Gut 2017. -
Identification of inflammatory mediators in patients with Crohn''s disease unresponsive to anti-TNFalpha therapy
Authors:Reference: Gut 2015. -
Transcriptional analysis of the intestinal mucosa of patients with ulcerative colitis in remission reveals lasting epithelial cell alterations
Authors:Reference: Gut 2013. -
Rolling adhesion through an extended conformation of integrin alphaLbeta2 and relation to alpha I and beta I-like domain interaction
Authors:Reference: Immunity 2004.
Featured Projects
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Pre-clinical development of the next generation of immunotherapies for diseases or disorders with unmet medical needs - FIBROTARGET
Principal investigator: Maria Azucena Salas MartinezFunder: Institut d'Investigacions Biomèdiques August Pi i Sunyer (Entidad de origen); European CommissionCode: 101080523Duration: 01/04/2023 - 01/03/2028 -
Estudio de la heterogeneidad en la enfermedad inflamatoria Intestinal mediante el uso de análisis de célula única
Principal investigator: Maria Azucena Salas MartinezFunder: Ministerio de Ciencia e InnovaciónCode: PID2021-123918OB-I00Duration: 01/09/2022 - 01/09/2025 -
Early detection of perianal fistulizing disease - Pathophysiology and Imaging
Principal investigator: Julian Panes Diaz, Maria Azucena Salas MartinezFunder: The Leona M. & Harry B. Helmsley Charity TrustCode: 2008-04050Duration: 01/11/2019 - 01/11/2022 -
Taxonomy, Treatment, Targets and Remission (3TR): Identification of the Molecular Mechanisms of non-response to Treatments, Relapses and Remission in Autoimmune, Inflammatory, and Allergic Conditions
Principal investigator: Juan de Dios Canete Crespillo, Maria Azucena Salas Martinez, Luis F Quintana Porras, Ricard Cervera Segura, Yolanda Blanco MorgadoFunder: European CommissionCode: CE_IMI2-2018-14Duration: 01/09/2019 - 31/08/2026 -
Dissecting the cellular basis of inflammatory bowel disease through single cell RNA sequencing (CELLBASE) the cellular basis of inflammatory bowel disease through single cell RNA sequencing (CELLBASE)
Principal investigator: Maria Azucena Salas Martinez, Julian Panes DiazFunder: Ministerio de Ciencia, Innovación y Universidades (Programa financiador competitivo)Code: RTI2018-096946-B-I00Duration: 01/01/2019 - 31/12/2021