Antonio Postigo

ICREA-IDIBAPS

Research group

Gene Regulation in Stem Cells, Cell Plasticity, Differentiation, and Cancer Group leader (R4)

idib412@recerca.clinic.cat 0000-0003-4605-2634

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Featured publications

Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation

Authors:
Martinez-Campanario, M C; Cortes, Marlies; Moreno-Lanceta, Alazne; Han, Lu; Ninfali, Chiara;

(...)

Escola-Gil, Joan C; de Frutos, Pablo Garcia; Andres, Vicente; Melgar-Lesmes, Pedro; Postigo, Antonio.

Reference: Nature Communications 2023.
Inflammatory macrophages reprogram to immunosuppression by reducing mitochondrial translation

Authors:
Cortes, Marlies; Brischetto, Agnese; Martinez-Campanario, M C; Ninfali, Chiara; Dominguez, Veronica;

(...)

Pintado, Belen; Morales-Ruiz, Manuel; Castro, Pedro; Canete, Juan D; Postigo, Antonio.

Reference: Nature Communications 2023.
The adaptive antioxidant response during fasting-induced muscle atrophy is oppositely regulated by ZEB1 and ZEB2

Authors:
Ninfali, C; Cortés, M; Martínez-Campanario, MC; Domínguez, V; Han, L;

(...)

Esteve-Codina, A; Enrich, C; Pintado, B; Garrabou, G; Postigo, A.

Reference: Proceedings Of The National Academy Of Sciences Of The United States Of America 2023.
The mesodermal and myogenic specification of hESCs depend on ZEB1 and are inhibited by ZEB2

Authors:
Ninfali, C; Siles, L; Esteve-Codina, A; Postigo, A;

Reference: Cell Reports 2023.
ZEB1 promotes inflammation and progression towards inflammation-driven carcinoma through repression of the DNA repair glycosylase MPG in epithelial cells

Authors:
de Barrios, Oriol; Sanchez-Moral, Lidia; Cortes, Marlies; Ninfali, Chiara; Profitos-Peleja, Nuria;

(...)

Castells, Antoni; Maurel, Joan; Salas, Azucena; Dean, Douglas C; Postigo, Antonio.

Reference: Gut 2019.
ZEB1 protects skeletal muscle from damage and is required for its regeneration

Authors:
Siles, L; Ninfali, C; Cortes, M; Darling, DS; Postigo, A;

Reference: Nature Communications 2019.
Regulation of muscle atrophy-related genes by the opposing transcriptional activities of ZEB1/CtBP and FOXO3

Authors:
Ninfali C; Siles L; Darling D; Postigo A;

Reference: Nucleic Acids Research 2018.
Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells

Authors:
Liu, Yongqing; Siles, Laura; Lu, Xiaoqin; Dean, Kevin C; Cuatrecasas, Miriam;

Postigo, Antonio; Dean, Douglas C.

Reference: Nature Communications 2018.
Tumor-associated macrophages (TAMs) depend on ZEB1 for their cancer-promoting roles

Authors:
Cortes, Marlies; Sanchez-Moral, Lidia; de Barrios, Oriol; Fernandez-Acenero, Maria J.; Martinez-Campanario, M. C.;

(...)

Darling, Douglas S.; Gyorffy, Balazs; Lawrence, Toby; Dean, Douglas C.; Postigo, Antonio..

Reference: Embo Journal 2017.
ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1

Authors:
de Barrios, Oriol; Gyorffy, Balazs; Jesus Fernandez-Acenero, Maria; Sanchez-Tillo, Ester; Sanchez-Moral, Lidia;

(...)

Roue, Gael; Casal, Jose I; Darling, Douglas S; Castells, Antoni; Postigo, Antonio.

Reference: Gut 2017.

Featured Projects

Cooperation and competition between colorectal carcinomas (CRC) and their tumor microenvironment: Validation of ZEB factors as prognostic and predictive biomarkers and therapeutic targets in CRC.

Principal investigator: Antonio Postigo

Funder: Fundació Olga Torres

Code: FUND.OLGATORRES_19_3

Duration: 01/01/2020 - 31/12/2021
Validation of ZEB factors as prognostic and predictive biomarkers and therapeutic targets in CRC

Principal investigator: Antonio Postigo

Funder: Asociación Española Contra el Cáncer (AECC).

Code: AECC_2019

Duration: 01/11/2019 - 31/10/2022
Validation of ZEB2 as a predictive predictive biomarker and potential therapeutic target in Duchenne muscular dystrophy

Principal investigator: Antonio Postigo

Funder: Duchenne Parent Project

Code: DPP-E-2018

Duration: 16/12/2018 - 15/12/2020

Antonio Postigo

Research group

Featured publications

Featured Projects

Cooperation and competition between colorectal carcinomas (CRC) and their tumor microenvironment: Validation of ZEB factors as prognostic and predictive biomarkers and therapeutic targets in CRC.

Validation of ZEB factors as prognostic and predictive biomarkers and therapeutic targets in CRC

Validation of ZEB2 as a predictive predictive biomarker and potential therapeutic target in Duchenne muscular dystrophy

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