Sònia Guedan

Grup de recerca

Immunoteràpies cel·lulars pel càncer Junior group leader (R3B)

sguedan@recerca.clinic.cat 0000-0002-9605-0760

Publicacions destacades

Time 2EVOLVE: predicting efficacy of engineered T-cells - how far is the bench from the bedside?

Autors:
Guedan, Sonia; Luu, Maik; Ammar, Delphine; Barbao, Paula; Bonini, Chiara;

(...)

Roberto Rodriguez-Madoz, Juan; Ruggiero, Eliana; Themeli, Maria; Hudecek, Michael; Marchiq, Ibtissam.

Referència: Journal For Immunotherapy Of Cancer 2022.
An NK-like CAR T cell transition in CAR T cell dysfunction

Autors:
Good, Charly R; Aznar, M Angela; Kuramitsu, Shunichiro; Samareh, Parisa; Agarwal, Sangya;

(...)

Albelda, Steven M; Lanier, Lewis L; Young, Regina M; Berger, Shelley L; June, Carl H.

Referència: Cell 2021.
Identification of cell surface targets for CAR-T cell therapies and antibody-drug conjugates in breast cancer

Autors:
Schettini, F; Barbao, P; Braso-Maristany, F; Galvan, P; Martinez, D;

Pare, L; De Placido, S; Prat, A; Guedan, S.

Referència: Esmo Open 2021.
Single residue in CD28-costimulated CAR-T cells limits long-term persistence and antitumor durability

Autors:
Guedan, Sonia; Madar, Aviv; Casado-Medrano, Victoria; Shaw, Carolyn; Wing, Anna;

Liu, Fang; Young, Regina M; June, Carl H; Posey, Avery D, Jr.

Referència: Journal Of Clinical Investigation 2020.
Engineering and Design of Chimeric Antigen Receptors

Autors:
Guedan, Sonia; Calderon, Hugo; Posey, Avery D, Jr; Maus, Marcela V;

Referència: Molecular Therapy-Methods & Clinical Development 2019.
Emerging Cellular Therapies for Cancer

Autors:
Guedan, Sonia; Ruella, Marco; June, Carl H;

Referència: Annual Review Of Immunology 2019.
Improving CART-Cell Therapy of Solid Tumors with Oncolytic Virus-Driven Production of a Bispecific T-cell Engager.

Autors:
Wing, Anna; Fajardo, Carlos Alberto; Posey, Avery D, Jr; Shaw, Carolyn; Da, Tong;

Young, Regina M; Alemany, Ramon; June, Carl H; Guedan, Sonia.

Referència: Cancer Immunology Research 2018.
Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation

Autors:
Guedan, Sonia; Posey, Avery D, Jr; Shaw, Carolyn; Wing, Anna; Da, Tong;

(...)

Lacey, Simon F; Scholler, John; Keith, Brian; Young, Regina M; June, Carl H.

Referència: Jci Insight 2018.
Distinct Signaling of Coreceptors Regulates Specific Metabolism Pathways and Impacts Memory Development in CAR T Cells

Autors:
Kawalekar, Omkar U; O'Connor, Roddy S; Fraietta, Joseph A; Guo, Lili; McGettigan, Shannon E;

(...)

Keith, Brian; Snyder, Nathaniel; Blair, Ian; Milone, Michael C; June, Carl H.

Referència: Immunity 2016.
Hyaluronidase Expression by an Oncolytic Adenovirus Enhances Its Intratumoral Spread and Suppresses Tumor Growth

Autors:
Guedan, Sonia; Jose Rojas, Juan; Gros, Alena; Mercade, Elena; Cascallo, Manel;

Alemany, Ramon.

Referència: Molecular Therapy 2010.

Projectes destacats

Fine-tuning T cell networks of exhaustion by synthetic sensors

Investigador/a principal: Sònia Guedan Carrió

Finançador: European Commission

Codi: HORIZON-EIC-2021-Pathfinder

Durada: 01/09/2022 - 30/08/2026
Development of enabling technologies for T-cell immunotherapy

Investigador/a principal: Sònia Guedan Carrió

Finançador: Fundación La Caixa

Codi: Health Research_2021

Durada: 01/10/2021 - 30/09/2024
T2EVOLVE: Accelerating Development and Improving Access to CAR and TCR-engineered T cell therapy

Investigador/a principal: Sònia Guedan Carrió

Finançador: European Commission

Codi: CE_IMI12_18th_2stg

Durada: 01/01/2021 - 31/12/2025
CAR-T cells as drug delivery agents for the treatment of solid tumors

Investigador/a principal: Sònia Guedan Carrió

Finançador: Asociación Española Contra el Cáncer

Codi: AECC_Lab20

Durada: 01/12/2020 - 29/02/2024
Chimeric Antigen Receptor (CAR)-modified T cells for the treatment of solid tumours

Investigador/a principal: Sònia Guedan Carrió

Finançador: Agencia Estatal de Investigacion (AEI)

Codi: PID2019-109546RA-I00

Durada: 01/06/2020 - 31/05/2023

Sònia Guedan

Grup de recerca

Publicacions destacades

Projectes destacats

Fine-tuning T cell networks of exhaustion by synthetic sensors

Development of enabling technologies for T-cell immunotherapy

T2EVOLVE: Accelerating Development and Improving Access to CAR and TCR-engineered T cell therapy

CAR-T cells as drug delivery agents for the treatment of solid tumors

Chimeric Antigen Receptor (CAR)-modified T cells for the treatment of solid tumours

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