Heterogeneïtat i plasticitat del microambient tumoral (TMHet)
Publicacions destacades
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Heterogeneity, crosstalk, and targeting of cancer-associated fibroblasts in cholangiocarcinoma
Vila, Paula Cantallops; Ravichandra, Aashreya; Lizaso, Alona Agirre; Perugorria, Maria J; Affo, Silvia;Referència:Hepatology 2024.
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Fibroblasts in liver cancer: functions and therapeutic translation
Affo, Silvia; Filliol, Aveline; Gores, Gregory J; Schwabe, Robert F;Referència:Lancet Gastroenterology & Hepatology 2023.
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Cholangiocarcinoma - novel biological insights and therapeutic strategies
Ilyas, Sumera I; Affo, Silvia; Goyal, Lipika; Lamarca, Angela; Sapisochin, Gonzalo;Yang, Ju Dong; Gores, Gregory J.Referència:Nature Reviews Clinical Oncology 2023.
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Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis
Filliol, Aveline; Saito, Yoshinobu; Nair, Ajay; Dapito, Dianne H; Yu, Le-Xing;(...)Zucman-Rossi, Jessica; Karin, Michael; Henderson, Neil C; Tabas, Ira; Schwabe, Robert F.Referència:Nature 2022.
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Cancer-associated fibroblasts in intrahepatic cholangiocarcinoma progression and therapeutic resistance
Ravichandra, Aashreya; Bhattacharjee, Sonakshi; Affo, Silvia;Referència:Advances In Cancer Research 2022.
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The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver
Mederacke, Ingmar; Filliol, Aveline; Affo, Silvia; Nair, Ajay; Hernandez, Celine;(...)Rothlin, Carla, V; Baehre, Heike; Tabas, Ira; Sancho-Bru, Pau; Schwabe, Robert F.Referència:Science Translational Medicine 2022.
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Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations
Affo, Silvia; Nair, Ajay; Brundu, Francesco; Ravichandra, Aashreya; Bhattacharjee, Sonakshi;(...)Seki, Ekihiro; Sia, Daniela; Chen, Xin; Califano, Andrea; Schwabe, Robert F.Referència:Cancer Cell 2021.
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The Role of Cancer-Associated Fibroblasts and Fibrosisin Liver Cancer
Affo, Silvia; Yu, Le-Xing; Schwabe, Robert F;Referència:Annual Review Of Pathology-Mechanisms Of Disease 2017.