Línies de recerca

• Study of the structure and function of the SLAM leukocyte molecules and their role in autoimmunity and cancer

  The SLAM receptors belong to a family of molecules expressed on lymphocytes and other leukocytes. We and other research has demonstrated that they pay key roles in the regulation of the immune response in a great variety of diseases. We are testing the therapeutic potential of monoclonal antibodies, produced in our laboratory, against these receptors in several mouse models of autoimmunity, and leukemia and lymphoma.

• Study of the structure and function of scavenger-like receptors and their role as inmunomodulators in infection, autoimmunity and cancer

  The Scavenger Receptor Cysteine-Rich Superfamily (SRCR-SF) is an ancient and highly conserved group of immune cell receptors involved in the development and regulation of innate and adaptive responses against pathogenic agents of both exogenous (infectious) or endogenous (cancerous) origin. By understanding the molecular interactions established between lymphoid and myeloid SRCR-SF receptors and such pathogenic agents we are currently testing the therapeutic potential of SRCR-based  biologicals in animal models of immune-mediated disorders.   

• Study of citomegalovirus (CMV) modulation of the immune response and viral immune evasion strategies

  Viruses have developed during their coevolution with their host powerful mechanisms of immune evasion. We are identified and describe the function of several of these molecules encoded by CMV. The knowledge generated by our results will allow us not only understand better how these viruses produce infections and also to develop novel strategies to manipulated the immune system.